A permutation method for detecting trend correlations in rare variant association studies
نویسندگان
چکیده
منابع مشابه
A novel statistical method for rare-variant association studies in general pedigrees
Both population-based and family-based designs are commonly used in genetic association studies to identify rare variants that underlie complex diseases. For any type of study design, the statistical power will be improved if rare variants can be enriched in the samples. Family-based designs, with ascertainment based on phenotype, may enrich the sample for causal rare variants and thus can be m...
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ژورنال
عنوان ژورنال: Genetics Research
سال: 2019
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s0016672319000120